After studying in the Seminary of Tui, he took a degree in Jurisprudence in Santiago, where he founded and edited the weekly paper La Armonía. Afterwards, he established himself in Madrid.
Leopoldo Martínez Padín wrote the first volume of Historia política, religiosa y descriptiva de Galicia (1849), his most important work. Besides, he wrote Suspiros del corazón (1845), the poetry titled A la Reina con motivo de su enlace con el Sr. Don Francisco de Asís (1846) and a composition titled A Galicia (1862).