His parents were emigrants and came to Galicia when he was a child. He studied Primary Education in A Coruña. Then he moved to Santiago with his family where he studied Secondary Education and Law some years later.Luis Seoane always took part in all the cultural initiatives of that moment. He collaborated with drawings and literary texts in the magazines Yunque, Universitarios, Alento and Nós.After he took his degree in Law, he moved to A Coruña to work as a lawyer. At the end of 1936 he went to Buenos Aires into exile, where he collaborated in different newspapers and magazines.
He made his first exhibition in 1929 at the Society Art Fiends of Santiago (Asociación Amigos del Arte de Santigo). In 1932 he began to illustrate books of his generation friends like Mar ao Norde, Poemas de si e non and Cantiga nova que se chama Riveira by Cunqueiro and Corazón ao vento by Iglesia Alvariño.In 1937, he made a collection of satirical drawings in Buenos Aires to report the events of the Spanish War, titled Trece estampas de la traición.In 1941, he published a lithography album with a poem by Rafael Dieste.In 1944, he published a collection of drawings titled Homenaje a la Torre de Hércules and the album of illustrations María Pita e tres retratos medievais.In this period, Luis Seoane also painted El Marinero con la red (1942), En la playa (1944), Mujer con caracola (1945), Joven peinándose (1945), El mendigo inválido (1947), Joven vestida de rojo (1948), Mozo con conejo (1948), Liando un cigarrillo (1949).The themes of his painting are varied (No parque (1945), El cazador (1950), Pelando patacas (1950), Crucifixión (1974) , El e ela (1976), O ferido (1977), Un anxo (1978)) and his versatile personality makes him know the technique of woodcut (El toro júbilo (1963), O Meco (1963), Homenaje a Venecia (1964), Imágenes de Galicia (1978), Bestiario (1965), Insectario (1975)), lithography (Muiñeira(1941), silkscreen printing (Campesinos (1954), El Circo (1974) and so forth.Apart from his artistic work he also published a volume of old and medieval Galician legends titled Tres hojas de ruda y un ajo verde and several studies and monograph essays about art.He published the theatre play La Soldadera about the ?irmandiñas? wars and El irlandés astrólogo.While he was living in Buenos Aires he took part in the creation of magazines and publishing houses; he organized courses and lectures, explained in Galician language, for Galician young people about Language and Literature and Geography and History; he made radio programmes and so on.
The Galician Academy dedicated him ?O Día das Letras Galegas? (The Day of the Galcian Letters) in 1994.