José R. Regueiro y González-Barros

Category: Biochemist
Birth Date: July 8, 1958
Birth Place: Santiago (A Coruña)
Correo electrónico: 
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1980: MSc. Biochemistry and Molecular Biology. Universidad Complutense (Madrid).
LANGUAGES: English (fluently), French (conversation), German (translation).

1981-84: HLA in reproduction and disease susceptibility. Complement immunogenetics. Department of Immunology (Prof. A. Arnaiz-Villena). Hospital Ramón y Cajal.
1981: Complement allotyping. Centre de Transfusion Sanguine (Dr. G. Hauptman). Strassbourg (France).
1982: MSc. Project on complement allotyping. Universidad Complutense (Madrid).
1984: Molecular Biology. Centre Hayem (Prof. D. Cohen, Prof. J. Dausset) Hòpital St. Louis (France).
1985: ScD, PhD in Immunology. Universidad Complutense (Madrid).
1984-86: Immunodeficiencies. Department of Immunology (Prof. A. Arnaiz-Villena). Hospital ‘12 de Octubre’ (Madrid).
1989: T cell biology. Department of Molecular Immunology (Prof. C. Terhorst). Dana Farber Cancer Institute. Boston (USA).

1986: Head of the Cellular and Humoral Immunology Laboratory. Department of Immunology (Prof. A. Arnaiz-Villena). Hospital ‘12 de Octubre’ (Madrid).
1989: Associate Professor of Immunology, School of Medicine, University of Valladolid. Board: Martínes-AC, López de Castro JA, Poljack R. Stutman O, Coutinho A, Rubinstein P, Palacios R, Parkhaus M.
1993: Associate Professor of Immunology, School of Medicine, Universidad Complutense (Madrid).
1995: Head, Center of Immunological Techniques, Universidad Complutense (Madrid).

 Work & Activities

1. HLA factors in non-insulin-dependent diabetes mellitus. Arnaiz-Villena A, Rodriguez Cordoba S, Regueiro JR, Bootello A, Serrano-Rios M. N Eng J Med 303,1065 (1980).
2. Several HLA haplotypic factors for both type 1 (insulin- dependent) and type 2 (non -insulin-dependent) diabetes. Serrano-Rios M, Regueiro JR, Severino R, Lopez-Larrea C, Arnaiz-Villena A. Diabetologia 25, 71 (1983)
3. HLA antigens in insulin dependent and non-insulin dependent Spanish diabetic patients. Serrano-Rios M, Regueiro JR, Severino R, López-Larrea C, Arnaiz-Villena A. Diabete Metab 9(2), 116-120 (1983)
4. Extended HLA haplotypes and Berger's disease. Arnaiz-Villena A, Gonzalo A, Regueiro JR, Vicario JL, Ortuño J. Clin Nephrol 22(6), 320-321 (1984).
5. DR, C4 and Bf allotypes in juvenile rheumatoid arthritis (JRA). Arnaiz-Villena A, Gomez-Reino JJ, Gamir ML, Regueiro JR, Vicario JL, Gomez-Reino FJ, Alonso A, Fernandez-Dapica MP, Irigoyen MV, Mateo I, Zea A. Arthritis Rheum 27, 1281-5 (1984).
6. HLA typing of dried sperm. Regueiro JR, Arnaiz-Villena A. J Forensic Sci (1984)
7. C3 polymorphism, HLA and chronic renal failure in Spaniards. Regueiro JR, Arnaiz-Villena A. Hum Genet 67, 437-40 (1984)
8. Immunofixation for C2 typing: C2 allotypes in Spaniards in relation to HLA, Bf and C4. Regueiro JR, Arnaiz-Villena A. Hum Genet 71, 58-61 (1985).
9. HLA-A, -B, -C, Bw4, Bw6 and -DR antigens are expressed on purified seminal cells other than spermatozoa. Rodriguez- Cordoba S, Regueiro JR, Arnaiz-Villena A. Scand J Immunol (1986)
10. +Familial defect of CD3 (T3) expression by T cells associated with rare gut epithelial cell autoantibodies. Regueiro JR, Arnaiz-Villena A, O de Landazuri M, Martin-Villa JM, Vicario JL, Pascual-Ruiz V, Guerra-Garcia F, Alcamí J, Lopez-Botet M, Manzanares J. Lancet 1, (1986).
11. Indomethacin in the relief of AIDS symptoms. Ramirez J, Alcami J, Arnaiz-Villena A, Regueiro JR, Rioperez E, Yagüe J, Fernandez F. Lancet 2, 570 (1986).
12. *An in vivo functional immune system lacking polyclonal T-cell surface expression of the CD3/Ti(WT31) complex. Regueiro JR, Lopez-Botet M, O de Landazuri M, Alcami J, Corell A, Martin- Villa JM, Vicario JL, Arnaiz-Villena A. Scand J Immunol 26 (1987).
13. Familial defect in the surface expression of the T-cell receptor/CD3 complex. Alarcon B, Regueiro JR, Arnaiz-Villena A, Terhorst C. N Eng J Med 319, 1203-1208 (1988).
14. Human MHC class III (Bf,C2,C4) genes and GLO: their association with other HLA antigens and extended haplotypes in the Spanish population. Regueiro JR, Arnaiz-Villena A. Tissue Antigens 31, 14-27 (1988).
15.* Cadaver Kidney transplant in hyperimmunized patients. Andres A, Morales JM, Prieto C, Clerici N, Arnaiz-Villena A, Vicario JL, Alcazar JM, Ruilope LM, Rodicio JL, Regueiro JR. Transpl Proc 20, 73-74 (1988).
16. a/b heterodimeric T-cell receptor expression early in thymocyte differentiation. Toribio ML, Hera A, Regueiro JR, Marquez C, R-Marcos M, Bragado R, Arnaiz-Villena A, Martinez- Alonso C. J Mol Cell Immunol 3, 347-362 (1988).
17. Progress in the classification of severe combined immunodeficiency. Regueiro JR, Perez-Aciego P, Manzanares J, Garcia-Hernandez G, Arnaiz-Villena A. Pediatrics 84, 196-7 (1989).
18. Antigen Society #15 Report (Bw4 and Bw6). Arnaiz-Villena A, Belvedere M, Decary F, Fotino M, Heise E, Hogan V, Martinetti M, Muller C, Richiardi P, Vicario JL, Barbanti M, Bruyere J, Mervart H, Peruccio D, Regueiro JR, Schreuder I. Histocompatibility testing 1987 (Immunobiology of HLA Vol I) Dupont B ed. Springer-Verlag, New York 1989.
19. RFLP Standardization Report for Class I/MspI. Tonks S, Groves V, Muller C, Otani F, Regueiro JR, Segall M, Bodmer J, Trowsdale J. Histocompatibility testing 1987 (Immunobiology of HLA Vol I) Dupont B ed. Springer-Verlag, New York 1989. p719-20
20. RFLP Standardization Report for Bf/MspI. Tonks S, Groves V, Muller C, Otani F, Regueiro JR, Segall M, Bodmer J, Trowsdale J. Histocompatibility testing 1987 (Immunobiology of HLA Vol I) Dupont B ed. Springer-Verlag, New York 1989. p732-33
21. RFLP Standardization Report for C2/MspI. Tonks S, Groves V, Muller C, Otani F, Regueiro JR, Segall M, Bodmer J, Trowsdale J. Histocompatibility testing 1987 (Immunobiology of HLA Vol I) Dupont B ed. Springer-Verlag, New York 1989. p752-53
22. RFLP Standardization Report for C4/MspI. Tonks S, Groves V, Muller C, Otani F, Regueiro JR, Segall M, Bodmer J, Trowsdale J. Histocompatibility testing 1987 (Immunobiology of HLA Vol I) Dupont B ed. Springer-Verlag, New York 1989. p769-70
23. RFLP Standardization Report for 21OH/MspI. Tonks S, Groves V, Muller C, Otani F, Regueiro JR, Segall M, Bodmer J, Trowsdale J. Histocompatibility testing 1987 (Immunobiology of HLA Vol I) Dupont B ed. Springer-Verlag, New York 1989. p786-87
24. RFLP Standardization Report for DR Alpha/MspI. Tonks S, Groves V, Muller C, Otani F, Regueiro JR, Segall M, Bodmer J, Trowsdale J. Histocompatibility testing 1987 (Immunobiology of HLA Vol I) Dupont B ed. Springer-Verlag, New York 1989. p805-06
25. RFLP Standardization Report for DP Alpha/MspI. Tonks S, Groves V, Muller C, Otani F, Regueiro JR, Segall M, Bodmer J, Trowsdale J. Histocompatibility testing 1987 (Immunobiology of HLA Vol I) Dupont B ed. Springer-Verlag, New York 1989. p846-47
26. *Workshop Report of RFLP in C4, C2, BF, and 21OH Genes. Alper C, Andreas-Zietz A, Arnaiz-Villena A, Dawkins R, Keller E, Partanen J, Regueiro JR. Histocompatibility testing 1987 (Immunobiology of HLA Vol I) Dupont B ed. Springer-Verlag, New York 1989.
27. *A novel polyclonal T-cell receptor expression defect probably not linked to HLA. Regueiro JR, Lopez-Botet M, O de Landazuri, Alcami J, Corell A, Martin-Villa JM, Martinez-Laso J, Perez-Aciego P, Vicario JL, Arnaiz-Villena A. Immunobiology of HLA. Vol II: Immunogenetics and Histocompatibility, p555-6, Dupont B ed., Springer-Verlag, New York (1989)
28. An EcoRI polymorphic site in the human complement component C4 genes distinguishes JRA susceptibility-bearing haplotypes. Arnaiz-Villena A, Vicario JL, Martinez-Laso J, Corell A, Regueiro JR, Gomez-Reino FJ, Gomez-Reino JJ. Mol Immunol (1989).
29. Description of an HLA-DQA1 RFLP allele (DQalpha4) defining DQw4/DRw8 bearing haplotypes. Martinez-Laso J, Vicario JL, Regueiro JR, Corell A, Artal P, Arnaiz-Villena A. Nucl Acid Res 17, 4006 (1989). IF3
30. A new HLA-DQA1-RFLP allele (DQalpha3b) distinguishes between DQalpha genes of DQw2-DR3 and DQw3-DR5 haplotypes. Martinez-Laso J, Vicario JL, Corell A, Morales P, Regueiro JR, Arnaiz-Villena A. Nucl Acid Res 17, 4911 (1989). IF3
31. Both HLA class II and III restriction length polymorphism factors linked to juvenile rehumatoid arthritis. Vicario JL, Martínez-Laso J, Regueiro JR, Serrano-Rios M, Arnaiz-Villena A. Clin Immunol Immunopathol 56, 22-28 (1990). IF3
32. Reversal of steroid- and antithymocyte globulin-resistant acute rejection crises in renal transplantation with monoclonal antibody (OKT3). Prieto C, Rodríguez-Paternina E, Andrés A, Morales JM, Farias J, Montoyo C, Regueiro JR, Rodicio JL.(1990)
33. *Low IgG2 and polysaccharide response in a T cell receptor expression defect. Regueiro JR, Perez-Aciego P, Aparicio P, Martinez-Alonso C, Morales P, Arnaiz-Villena A. Eur J Immunol 11, 2411-16 (1990). IF6
34. HLA-D determinants are expressed on human seminal cells other than spermatozoa but not on purified spermatozoa. Rodriguez-Cordoba S, Regueiro JR, Arnaiz-Villena A. J Reprod Immunol 18,237-45 (1990). IF2
35.R *T-cell receptor immunodeficiency in man. Alarcón B, Perez-Aciego P, Arnaiz- Villena A, Terhorst C, Regueiro JR. Immunodef Rev 2 (1990)
36.* Differential estimated HLA haplotype frequencies in young and adult insulindependent diabetics. Regueiro JR, Martin-Villa JM, Arnaiz- Villena A. Tissue Antigens (1990).
37. Shared SstI RFLps by HLA-Aw19, A23/24 and A3/11 crossreacting groups. Segurado O, Iglesias P, Vicario JL, Corell A, Regueiro JR, Arnaiz-Villena A. Tissue Antigens (1990).
38. Lack of preferential transmission of diabetic HLA alleles by healthy parents to offspring in Spanish diabetic families. Martin-Villa JM, Vicario JL, Martinez-Laso J, Serrano-Rios M, Lledo G, Damiano A, Hawkins F, Regueiro JR, Arnaiz- Villena A. J (1990)
39. Cutaneous lesions in severe combined immunodeficiency: two case reports and a review of the literature. Postigo-Llorente C, Ivars-Amoros J, Ortiz-de Frutos FJ, Regueiro JR, Llamas-Martín R, Guerra-Tapia A, Iglesias-Díez L. Pediatr Dermatol (1991)
40. *Acquired selective signature dysgraphia. Regueiro AM, Segurado OG., Mata P, Regueiro JR. Ann Neurol 31, 115 (1991). IF8
41. *A diallelic RFLP of the CD3 echain of the clonotypic T lymphocyte receptor is not associated to certain autoimmune diseases. Timon M, Arnaiz-Villena A, Perez-Aciego P, Morales P, Regueiro JR. Hum Genet 86, 363-364 (1991).
42. +Expression and function of a variant T-cell receptor complex lacking CD3 g.Pérez-Aciego P, Alarcón B, Arnaiz-Villena A, Terhorst C, Timón M, Segurado O, Regueiro JR. J. Exp Med 174, 319-326 (1991). IF14
43. T lymphocyte dysfunctions occurring together with apical gut epithelial cell autoantibodies. Martin-Villa JM, Regueiro JR, de Juan D, Perez-Aciego P, Perez-Blas M, Manzanares J, Varela P, Arnaiz-Villena A. Gastroenterology 101, 390-397 (1991). IF7
44. *Biochemical basis of a novel T-lymphocyte receptor immunodeficiency by immunohistochemistry: a possible CD3 gabnormality. Arnaiz-Villena A., Perez-Aciego P, Ballestín C, Sotelo T, Perez-Seoane C, Martin-Villa JM, Regueiro JR. Lab Invest (1991).
45. *Impaired T cell signal transduction through CD28 in a patient with idiopathic thrombocytopenia. Pérez-Blas M, Arnaiz-Villena A, Góngora R, Segurado OG, Vivanco JL, Regueiro JR. Clin Exp Immunol 85, 424-428 (1991). IF3
46. *T cell function in patients with impaired antibody responses to polysaccharide antigens. Reply. Regueiro JR, Pérez-Aciego P, Timón M, Morales P, Pérez-Blas M, Arnaiz-Villena A. Eur J. Immunol 21, 2293-96 (1991). IF6
47. *T-lymphocyte anergy during infectious mononucleosis is restricted to the clonotypic receptor activation pathway. Regueiro JR/Perez-Blas M, Ruiz-Contreras J, Arnaiz-Villena A. Clin Exp Immunol 89, 83-88 (1992).
48. +Primary immunodeficiency caused by mutations in the CD3 gsubunit of the T-lymphocyte receptor. Arnaiz-Villena A, Timón M, Corell, Pérez-Aciego P, Martín-Villa JM, Regueiro JR. New Eng J Med 327, 529-533 (1992). IF23
49.R +Human T-cell activation deficiencies. Arnaiz-Villena A, Timón M, Rodríguez-Gallego C, Pérez-Blas M, Corell A, Martín-Villa JM, Regueiro JR. Immunology Today 13,(1992).
50.R *From pathology to physiology of the human T-lymphocyte receptor. Regueiro JR, Timón M, Pérez-Aciego P, Corell A, Martín-Villa JM, Rodríguez-Gallego C, Góngora R, Arnaiz-Villena A. Scand J Immunol 36, 363-369 (1992). IF2
51.* CD11b-bearing mononuclear leukocytes and IgA levels in the staging of human immunodeficiency virus infection in Spaniards. Rivera-Guzmán JM, Regueiro JR, Alcamí J, Arnaiz-VillenaA. Experientia 48, 402-404 (1992). IF1
52. +Selective disbalances of peripheral blood T lymphocyte subsetsin human CD3 gdeficiency. Timón M, Arnaiz-Villena A, Rodríguez-Gallego C, Pérez-Aciego P, Pacheco A, Regueiro JR. Eur J Immunol 23, 1440-1444 (1993). IF6
53.R *T-cell activation. Terhorst C, Regueiro JR. In: Clinical aspects of Immunology (Lachmann PJ, Peters DK, Rosen FS, Walport MJ editors) Blackwell Sci. Pub., Boston (1993)
54.*Selective impairment of T-lymphocyte activation through the T-cell receptor/CD3 complex after cytomegalovirus infection. Timón M, Arnaiz-Villena A, Ruíz-Contreras J, Ramos-Amador JT, Pacheco A, Arnaiz-Villena A. (1993). IF3
55.* A decrease in the estimated extended HLA haplotype B18 CF130 DR3 DQw2 is common to non-insulin-dependent diabetes, juveline rheumatoid arthritis and Berger's disease. Regueiro JR, Arnaiz-Villena A, Vicario JL, Martínez-Laso J, Pacheco A. Experientia 49, 324-331 (1993). IF1
56.* T lymphocyte signaling defects and immunodeficiency due to the lack of CD3 g.Arnaiz-Villena A, Timón M, Rodríguez-Gallego C, Iglesias-Casarrubios P, Regueiro JR. Immunodeficiency 4, 121-129 (1993).
57. Peripheral blood reduction of memory (CD29+, CD45R0+ and ‘bright’ CD2+ and LFA-1+) T lymphocytes in Papillon-Lefévre syndrome. Góngora R, Corell A, Regueiro JR, Carasol M, Rodriguez-Gallego C, Paz-Artal E, Timón M, Allende L, Arnaiz A. Hum Immunol 41,185-192 (1994). IF3
58.* Primary T-lymphocyte immunodeficiency associated to a selective impairment of CD2, CD3, CD43 (but not CD28)- mediated signal transduction. Rodriguez-Gallego C, Arnaiz-Villena A, Corell A, Manzanares J, Timón M, Pacheco A, Regueiro JR. Clin Exp Immunol 97,386-391 (1994). IF3
59.R *Human T-lymphocyte activation deficiencies. Regueiro J.R, Rodriguez-Gallego C, Arnaiz-Villena A. Medical Intelligence Unit. R.G. Landes Company Pub, Austin, Texas (1994).
60.R *Diseases involving the T-cell receptor/CD3 complex. Timón M, Arnaiz Villena A, Rodríguez Gallego C, Pacheco A, Regueiro JR. Crit Rev Oncol Hematol 19 (1995).
61.R *T-lymphocyte receptor deficiencies. Kappes D, Alarcón B, Regueiro JR. Curr Opin Immunol 7, 441-447 (1995).
62. Diploid expression of HLA class I and II molecules on spermatozoa and their cyclic control by inhibin. Martín-Villa JM, Luque I, Martínez N, Corell A, Regueiro JR, Timón M, Arnaiz-Villena A. Biol Reprod (1996).
63.* Herpesvirus saimiri transformation of T cells in a CD3 gimmunodeficiency: phenotypical and functional characterization. Rodriguez-Gallego C, Corell A, Pacheco A, Timón M, Regueiro JR, Allende LM, Madroño A, Arnaiz-Villena A. J Immunol Methods 198, 177-186 (1996)
64.* Herpesvirus saimiri immortalization of a b and g d human T-lineage cells derived from CD34 +intrathymic precursors in vitro. Pacheco-Castro A, Márquez C, Toribio ML, Ramiro A, Trigueros C, Regueiro JR. Int. Inmunol 8, 1797-1805 (1996). IF4
65.* Construction of retroviral vectors carrying human CD3 gcDNA and reconstitution of CD3 gexpression and T cell receptor surface expression and function in a CD3 g-deficient mutant T cell line Sun J, Pacheco-Castro A, Borroto A, Alarcón B, Alvárez Zapata D an DRegueiro JR. Hum Gene Therapy 8 (9): 1041-1048 (1997). IF9
66.* Phenotypical and functional characterization of Herpesvirus saimiri-immortalized human major histocompatibility complex class II-deficient T lymphocytes. Alvarez-Zapata D, de Miguel-Olalla S, Fontán G, Ferreira A, García-Rodríguez MC, Madero L, van den Elsen P, Regueiro JR .Tissue Antigens, 51: 250-257 (1998)
67.ª Model for ATM Heterozygote Identification in a Large Population: Four Founder-Effect ATM Mutations Identify Most of Costa Rican Patients with Ataxia Telangiectasia. Telatar M, Wang Z, Castellvi-Bel S, Tai L-Q, Sheikhavandi S, Regueiro JR, Porras O and Gatti RA. Mol Gen Metab 64, 36-43 (1998)
68.* Signaling through a CD3 g-deficient T cell antigen receptor/CD3 complex in immortalized CD4 +and CD8 +T lymphocytes .Pacheco-Castro A, Alvárez Zapata D, Serrano-Torres P and Regueiro JR. J Immunol 161, 3152-60 (1998). IF7
69. R* CD3 deficiencies. Regueiro JR, Pacheco A, Alvarez-Zapata D, Corell A, Sun JY, Millán R, Arnaiz-Villena A. In: Primary immunodeficiency diseases, a molecular and genetic approach. H. Ochs, J. Puck, E. Smith eds. Oxford University, pp 189-197 (1999)
70. Conformational and biochemical differences in the TCR/CD3 complex of CD8+ vs CD4+ mature lymphocytes revealed in the absence of CD3 g.Alvarez D., Pacheco A. , Serrano P., Ramiro A., Toribio ML., Alarcón B., Rubin B., Alibaud L., Regueiro JR. (1999).
71. Zapata DA, Pacheco-Castro A, Torres PS, Millán R, Regueiro JR .CD3 immunodeficiencies . Immunol Allergy Clin 20 (1): 1-17 (2000). IF1
72. Regueiro J.R, Porras O, Lavin M and Gatti R .ATAXIA-TELANGIECTASIA.
A Primary immunodeficiency Revisited . Immunol Allergy Clin 20 (1): 177-206 (2000). IF1
73. Rivero ME, Porras O, Pelaez B, Pacheco A. Gatti R, Regueiro JR ,Membrane and transmembrane signaling in Herpesvirus saimiri-immortalized CD4+ and CD8+ T lymphocytes is ATM- independent . Int Immunol (2000). Transmitting editor:T Saito.
74. Cabanillas JA, Cambronero R, Pacheco A, García Rodríguez MC, Martín Fernández JM, Fontán G, Regueiro JR .Characterization of Herpesvirus saimiri-Transformed T Lymphocytes from Common Variable Immunodeficiency Patients (2002)
75. Cabanillas JA, Pachecho Castro A, Zapata DA, Torres PS, Martín Fernández JM, Millán R, Regueiro JR .T- cell transformation with Herpesvirus saimiri: a tool for primary Immunodeficiencies research . Recent Res Devel Immunology 4: 381-94 (2002).
76. Karim MA, Suzuki K, Fukai K, Oh J, Nagle DL, Moore KJ, Barbosa E, Falik-Borenstein T, Filipovich A, Ishida Y, Kivrikko S, Klein C, Kreuz F, Levin A, Miyajima H, Regueiro J, Russo C, Uyama E, Vierimaa O, Spritz RA .Apparent genotype-phenotype correlation in childhood, adolescent, and adult Chediak-Higashi syndrome . Am J Med Genet (2002)
77. Torres PS, Zapata DA, Pacheco A, Rodríguez-Fernández JL, Cabañas C, Regueiro JR. Contribution of CD3gamma to T-cell receptor regulation and signaling in human mature T lymphocytes . Int Immunol 14: 1357-67(2002). Transmitting editor: F Rosen IF3,6
78. Matheux F, Ikinciogullari A, Zapata DA, Barras E, Zufferey M, Dogu F, Regueiro JR, Reith W, Villard J. 2002. Direct Genetic Correction as a New Method for Diagnosis and Molecular Characterization of MHC Class II Deficiency. Molecular Therapy 6:824-9.
79. Torres PS, Alcover A, Zapata DA, Arnaud J, Pacheco A, Martín-Fernández JM, Villasevil EM, Sanal O, Regueiro JR. TCR dynamics in human mature T lymphocytes lacking CD3 g.J Immunol (2003).
80. Pacheco-Castro A, Martín-Fernadez JM, Millán R, Sanal O, Allende L, Regueiro JR. Toward gene therapy for human CD3 deficiencies .Hum Gene Therapy 14, (2003).
81. Zapata DA, Schamel WW, Torres PS, Alarcon B, Rossi NE, Navarro MN, Toribio ML, Regueiro JR. Biochemical Differences in the ab TCR·CD3 Surface Complex between CD8 +and CD4 +Human Mature T Lymphocytes .J Biol Chem 279 (2004).
82. Martín-Fernández JM, Cabanillas JA, Rivero M, Lacasa E, Pardo J, Anel A, Rodríguez-Duque PR, Merino F, Rodríguez-Gallego C, Regueiro JR. Herpesvirus saimiri-transformed CD8+ T cells as a tool to study Chediak-Higashi syndrome cytolytic lymphocytes. J Leukoc Biol (2005).